Tiger Woods and Trevor Immelman will both miss the 2008 Players Championship at TPC Sawgrass, which starts Thursday.
Woods is recovering from knee injury, while Immelman recently withdrew due to illness.
Immelman has failed to break par in his last two tournaments, missing the cut at the EDS Byron Nelson Championship and the Wachovia Championship.
Immelman was replaced by Dustin Johnson, a 23-year-old rookie.
The Players Championship is considered the fifth major in the PGA. It has the largest purse in golf, $9.5 million. It has a strong field as 47 of the 48 winners on Tour the past two years.
TPC at Sawgrass, which is located in Ponte Vedra Beach, Florida, is also home to the PGA Tour's headquarters.