The grizzly bear featured in Will Ferrell’s movie Semi Pro has attacked and killed a 39-year-old trainer at a Hollywood animal sanctuary.

Five year old Rocky was restrained with pepper spray after biting Stephan Miller on the neck at the Predators in Action facility in Big Bear, California, which is owned by his cousin Randy Miller.

Medics were called after the attack on Tuesday, but were unable to revive Miller.

Rocky - who is 2.3 metres (7.5 feet) tall and weighs 700 pounds - wrestled with Ferrell in his recent movie, and was recently described by Randy Miller as "the best bear in the business".

The Department of Fish and Game will now decide Rocky’s fate, following an investigation.